LINEAS DE INVESTIGACIÓN

1) Estudio de la participación de los productos finales de glicación avanzada (AGEs) en la etiopatogenia de la diabetes mellitus y sus complicaciones crónicas.

2) Estudio de los componentes del síndrome metabólico inducido por consumo crónico de sacarosa en un modelo de ratas.


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

1) Circulating Concentrations of Advanced Glycation end Products, its Association With the Development of Diabetes Mellitus. Itzel Uribe Jiménez, Eulises Díaz-Díaz, Jorge Salmerón Castro, Julia Pérez Ramos, Mario Cárdenas León, José Antonio Alvarado Ríos, Juan Carlos Auriostigue Bautista, Ricardo Correa-Rotter, Carlos Alberto Aguilar Salinas, and Fernando Larrea. Archives of Medical Research. 2017 (Received for publication July 12, 2016; accepted July 3, 2017 (ARCMED-D-16-00406). En prensa.

2) Fenofibrate Therapy Restores Antioxidant Protection and Improves Myocardial Insulin Resistance in a Rat Model of Metabolic Syndrome and Myocardial Ischemia: The Role of Angiotensin II. Ibarra-Lara L, Sánchez-Aguilar M, Sánchez-Mendoza A, Del Valle-Mondragón L, Soria-Castro E, Carreón-Torres E, Díaz-Díaz E, Vázquez-Meza H, Guarner-Lans V, Rubio-Ruiz ME. Molecules. 2016 Dec 28;22(1). pii: E31. doi: 10.3390/molecules22010031. PMID: 28036029.

3) Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats. Pérez-Torres I, Torres-Narváez JC, Pedraza-Chaverri J, Rubio-Ruiz ME, Díaz-Díaz E, Del Valle-Mondragón L, Martínez-Memije R, Varela López E, Guarner-Lans V. Molecules. 2016 Oct 26;21(11). pii: E1425. PMID: 27792195.

4) The Efficacy of Pregabalin in the Treatment of Prediabetic Neuropathic Pain. González-Duarte A, Lem M, Díaz-Díaz E, Castillo C, Cárdenas-Soto K. Clin J Pain. 2016 Nov;32(11):927-932. PMID: 26670614.

5) Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model. López YR, Pérez-Torres I, Zúñiga-Muñoz A, Lans VG, Díaz-Díaz E, Castro ES, Espejel RV. Curr Drug Deliv. 2016;13(1):158-69. PMID: 26996629.

6) The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue. Peredo-Escárcega AE, Guarner-Lans V, Pérez-Torres I, Ortega-Ocampo S, Carreón-Torres E, Castrejón-Tellez V, Díaz-Díaz E, Rubio-Ruiz ME. Evid Based Complement Alternat Med. 2015;2015:474032. doi: 10.1155/2015/474032. PMID: 26609312.

7) 17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats. Zúñiga-Muñoz AM, Guarner Lans V, Soria-Castro E, Diaz-Diaz E, Torrico-Lavayen R, Tena-Betancourt E, Pérez-Torres I. Int J Endocrinol. 2015;2015:149408. doi: 10.1155/2015/149408. PMID: 26491436.

8) Novel association of the R230C variant of the ABCA1 gene with high triglyceride levels and low high-density lipoprotein cholesterol levels in Mexican school-age children with high prevalence of obesity. Gamboa-Meléndez MA, Galindo-Gómez C, Juárez-Martínez L, Gómez FE, Diaz-Diaz E, Ávila-Arcos MA, Ávila-Curiel A. Arch Med Res. 2015 Aug;46(6):495-501. doi: 10.1016/j.arcmed.2015.07.008. PMID: 26256050.

9) Adipose tissue redistribution caused by an early consumption of a high sucrose diet in a rat model. Castellanos Jankiewicz AK, Rodríguez Peredo SM, Cardoso Saldaña G, Díaz Díaz E, Tejero Barrera ME, del Bosque Plata L, Carbó Zabala R. Nutr Hosp. 2015 Jun 1;31(6):2546-53. doi: 10.3305/nh.2015.31.6.8935. PMID: 26040364.

10) Non-steroidal anti-inflammatory drugs attenuate the vascular responses in aging metabolic syndrome rats. Rubio-Ruiz ME, Pérez-Torres I, Diaz-Diaz E, Pavón N, Guarner-Lans V. Acta Pharmacol Sin. 2014 Nov;35(11):1364-74. doi: 10.1038/aps.2014.67. PMID: 25263337.

11) Modulation of the activities of catalase, Cu-Zn, Mn superoxide dismutase, and glutathione peroxidase in adipocyte from ovariectomised female rats with metabolic syndrome. Guerra RC, Zuñiga-Muñoz A, Guarner Lans V, Díaz-Díaz E, Tena Betancourt CA, Pérez-Torres I. Int J Endocrinol. 2014;2014:175080. doi: 10.1155/2014/175080. PMID: 24987414.

12) Angiotensin II and 1-7 during aging in Metabolic Syndrome rats. Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue. Rubio-Ruíz ME, Del Valle-Mondragón L, Castrejón-Tellez V, Carreón-Torres E, Díaz-Díaz E, Guarner-Lans V. Peptides. 2014 Jul;57:101-8. doi: 10.1016/j.peptides.2014.04.021. PMID: 24819472.

13) Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats. Ruiz-Ramírez A, Ortiz-Balderas E, Cardozo-Saldaña G, Diaz-Diaz E, El-Hafidi M. Clin Sci (Lond). 2014 Jan 1;126(1):19-29. doi: 10.1042/CS20130164. PMID: 23742196.

14) Modification of the liver fatty acids by Hibiscus sabdariffa Linnaeus (Malvaceae) infusion, its possible effect on vascular reactivity in a metabolic syndrome model. Pérez-Torres I, Zúñiga Muñoz A, Beltrán-Rodríguez U, Díaz-Díaz E, Martínez-Memije R, Guarner Lans V. Clin Exp Hypertens. 2014;36(3):123-31. doi: 10.3109/10641963.2013.789046. PMID: 23734849.

15) Serum 25-hydroxyvitamin D levels among Mexican children ages 2 y to 12 y: a national survey. Flores M, Macias N, Lozada A, Sánchez LM, Díaz E, Barquera S. Nutrition. 2013 May;29(5):802-4. doi: 10.1016/j.nut.2012.12.024. PMID: 23422537.