LINEAS DE INVESTIGACIÓN

Estudio de los mecanismos moleculares y epigenéticos involucrados en la patogénesis de las enfermedades autoinmunes inflamatorias.


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.

Rodríguez-Rodríguez N, Madera-Salcedo IK, Cisneros-Segura JA, García-González HB, Apostolidis SA, Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-Rodríguez DP, Tsokos GC, Alcocer-Varela J, Rosetti F, Crispín JC.J Clin Invest. 2020 Nov 2;130(11):5989-6004. doi:

10.1172/JCI129479.PMID: 32750040



PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.

Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC.JCI Insight. 2019 Jul 23;5(16):e126457. doi:

10.1172/jci.insight.126457.PMID: 31335320



Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation.

Madera-Salcedo IK, Danelli L, Tiwari N, Dema B, Pacreau E, Vibhushan S, Birnbaum J, Agabriel C, Liabeuf V, Klingebiel C, Menasche G, Macias-Silva M, Benhamou M, Charles N, González-Espinosa C, Vitte J, Blank U.Sci Signal. 2018 Jul 3;11(537):eaan4350. doi:

10.1126/scisignal.aan4350.PMID: 29970602



Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury.

Danelli L, Madjene LC, Madera-Salcedo I, Gautier G, Pacreau E, Ben Mkaddem S, Charles N, Daugas E, Launay P, Blank U.J Immunol. 2017 Mar 15;198(6):2374-2382. doi:

10.4049/jimmunol.1601282. Epub 2017 Feb 6.PMID: 28167630