Departamento de Biología de la Reproducción


Dr. David Barrera Hernández

(55) 5487-0900 Ext. 2418
david.barrerah@incmnsz.mx

GRADO ACADÉMICO: Doctorado
CATEGORÍA: Investigador en Ciencias Médicas D
SISTEMA NACIONAL DE INVESTIGADORES Nivel II

 

LINEAS DE INVESTIGACIÓN

Metabolismo y efectos de la 1a,25-dihidroxivitamina D en la placenta humana y líneas celulares de cáncer.


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

García-Olivares M, Romero-Córdoba S, Ortíz-Sánchez E, García-Becerra R, Segovia-Mendoza M, Rangel-Escareño C, Halhali A, Larrea F, Barrera D. Regulation of anti-tumorigenic pathways by the combinatory treatment of calcitriol and TGF-β in PC-3 and DU145 cells. Journal of Steroid Biochemistry and Molecular Biology. 209:105831, 2021.

Caballero-Campo P, Lira-Albarrán S, Barrera D, Borja-Cacho E, Godoy-Morales HS, Rangel-Escareño C, Larrea F, Chirinos M. Gene transcription profiling of astheno- and normo-zoospermic sperm subpopulations. Asian Journal of Andrology. 22(6):608-615, 2020.

Segovia-Mendoza M, Camacho-Camacho C, Rojas-Oviedo I, Prado-García H, Barrera D, Martínez-Reza I, Larrea F, García-Becerra R. An organotin indomethacin derivative inhibits cancer cell proliferation and synergizes the antiproliferative effects of lapatinib in breast cancer cells. American Journal of Cancer Research. 10(10):3358-3369, 2020.

Urban-Sosa VA, Olvera-Sánchez S, Barrera D, Aragón-Hernández JP, Flores-Herrera O, Martínez F. Isocitrate dehydrogenase type 2 (IDH2) is part of a multiprotein complex for placental steroidogenesis. Placenta. 87:30-37, 2019.

Martínez-Reza I, Díaz L, Barrera D, Segovia-Mendoza M, Pedraza-Sánchez S, Soca-Chafre G, Larrea F, García-Becerra R. Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α. Journal of Immunology Research. 2019:6384278, 2019.

Noyola-Martínez N, Halhali A, Barrera D. Steroid hormones and pregnancy. Gynecological Endocrinology. 22:1-9 2019.

Lira-Albarrán S, Durand M, Barrera D, Vega C, Becerra RG, Díaz L, García-Quiroz J, Rangel C, Larrea F. A single preovulatory administration of ulipristal acetate affects the decidualization process of the human endometrium during the receptive period of the menstrual cycle. Molecular and Cellular Endocrinology. 476:70-78, 2018.

Lira-Albarrán S, Durand M, Larrea-Schiavon MF, González L, Barrera D, Vega C, Gamboa-Domínguez A, Rangel C, Larrea F. Ulipristal acetate administration at mid-cycle changes gene expression profiling of endometrial biopsies taken during the receptive period of the human menstrual cycle. Molecular and Cellular Endocrinology. 447:1-11, 2017.

García-Quiroz J, García-Becerra R, Lara-Sotelo G, Avila E, López S, Santos-Martínez N, Halhali A, Ordaz-Rosado D, Barrera D, Olmos-Ortiz A, Ibarra-Sánchez MJ, Esparza-López J, Larrea F, Díaz L. Chronic moderate ethanol intake differentially regulates vitamin D hydroxylases gene expression in kidneys and xenografted breast cancer cells in female mice. Journal of Steroid Biochemistry and Molecular Biology. 173:148-156, 2017.

Noyola-Martínez N, Halhali A, Zaga-Clavellina V, Olmos-Ortiz A, Larrea F, Barrera D. A time-course regulatory and kinetic expression study of steroid metabolizing enzymes by calcitriol in primary cultured human placental cells. The Journal of Steroid Biochemistry and Molecular Biology. 167:98-105, 2017.

Silva-Ortiz AV, Bratoeff E, Ramírez-Apan MT, García-Becerra R, Ordaz-Rosado D, Noyola-Martínez N, Castillo-Bocanegra R, Barrera D. Synthesis and biological activity of two pregnane derivatives with a triazole or imidazole ring at C-21. The Journal of Steroid Biochemistry and Molecular Biology. 159:8-18, 2016.

Olmos-Ortiz A, García-Quiroz J, López-Marure R, González-Curiel I, Rivas-Santiago B, Olivares A, Avila E, Barrera D, Halhali A, Caldiño F, Larrea F, Díaz L. Evidence of sexual dimorphism in placental vitamin D metabolism: Testosterone inhibits calcitriol-dependent cathelicidin expression. The Journal of Steroid Biochemistry and Molecular Biology. (16)30147-9, 2016.