LINEAS DE INVESTIGACIÓN

Luigi's Lab utilizes a multi-disciplinary approach to investigate the molecular and genetic bases of human congenital gonad (Disorders of Sex Development) and endocrine diseases; likewise, gene regulation by steroid hormones.


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

Ramos L (2023) A Novel Heterozygous SF1/NR5A1 Gene Variant Causes 46,XY DSD-Gonadal Dysgenesis With Hypergonadotropic Hypogonadism Without Adrenal Insufficiency. Genes Dis. https://doi.org/10.1016/j.gendis.2023.101160



Martínez-Gómez LE, Martinez-Armenta C, Medina-Luna D, Ordoñez-Sánchez ML, Tusie-Luna T, Ortega-Peña S, Herrera-López B, Suarez-Ahedo C, Jimenez-Gutierrez GE, HidalgoBravo A, Vázquez-Cárdenas P, Vidal-Vázquez RP, Ramírez-Hinojosa JP, Martinez Matsumoto PM, Vargas-Alarcón G, Posadas-Sánchez R, Fragoso J‐M, Martínez-Ruiz FdJ, Zayago-Angeles DM, MataMiranda MM, Vázquez-Zapién GJ, Martínez-Cuazitl A, Andrade-Alvarado J, Granados J, Ramos-Tavera L, Camacho-Rea MdC, Segura-Kato Y, Rodríguez-Pérez JM, Coronado-Zarco R, Franco-Cendejas R, López-Jácome LE, Magaña JJ, Vela-Amieva M, Pineda C, Martínez-Nava GA, López-Reyes A (2023) Implication of Myddosome complex genetic variants in outcome severity of COVID-19 patients, J Microbiol Immunol Infect, https://doi.org/10.1016/j.jmii.2023.06.002



Ramos L (2023) Dimorphic frataxin and its gene regulation by sex steroids in hamsters. Mol Genet Genomics. DOI:10.1007/s00438-023-02004-6



Ramos L (2022) WT1, NR0B1, NR5A1, LHX9, ZFP92, ZNF275, INSL3, and NRIP1 Genetic Variants in Patients with Premature Ovarian Insufficiency in a Mexican Cohort. Genes 13, 4, 611. doi: 10.3390/genes13040611



Laura E. Mártinez-Gómez, Brígida Herrera-López, Carlos Martinez-Armenta, Silvestre Ortega-Peña, María Carmen Camacho-Rea, Carlos Suarez-Ahedo, Paola Vázquez-Cárdenas, Gilberto Vargas Alarcón, Jose Manuel Fragoso, Gustavo Rojas-Velasco, Rosa P Vidal-Vázquez, Juan P Ramírez-Hinojosa, Yunuen Rodríguez-Sánchez, Rafael Barron-Díaz, Mariana L Moreno, Felipe de J Mártinez-Ruiz, Dulce M Zayago-Angeles, Mónica Maribel Mata-Miranda, Gustavo Jesús Vázquez-Zapién, Adriana Martínez-Cuatzitl, Edith Barajas-Galicia, Ludwing Bustamante-Silva, Diana Zazueta-Arroyo, José Manuel Rodríguez-Pérez, Olivia Hernández-González, Roberto Coronado-Zarco, V Lucas-Tenorio, Rafael Franco-Cendejas, Luis Esau Lopez Jacome, Rocío Carmen Vázquez-Juárez, Jonathan J Magaña, Marlid Cruz-Ramos, Julio Granados, Susana Hernández-Doño, Diego Delgado Zaldivar, Luis Ramos-Tavera, Irma Coronado-Zarco, Gustavo Guajardo-Salinas, Jóse Francisco Muñoz-Valle, Carlos Pineda, Gabriela Angelica Martínez-Nava, Alberto López-Reyes (2022) ACE and ACE2 gene variants are associated with severe outcomes of COVID-19 in males. Front Immunol 13, 812940. doi: 10.3389/fimmu.2022.812940



Ramos L, Mares L, (2021) Hamster DAX1: Molecular insights, specific expression, and its role in the Harderian gland. Comp Biochem Physiol A Mol Integr Physiol 263, 111096. doi: 10.1016/j.cbpa.2021.111096



Mares L, Ramos L, (2021) Harderian SOX9: Molecular characterization and its dimorphic expression in hamster. Comp Biochem Physiol A Mol Integr Physiol 258, 110981. doi: 10.1016/j.cbpa.2021.110981



Orozco M, Valdez R, Ramos L, Cabezas M, Segovia J, Romano MC (2020) Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 metabolism, proliferation, and invasion capacity: Androgen regulation. Steroids 164, 108733. doi: 10.1016/j.steroids.2020.108733



Mares L., Vilchis F., Chávez B., Ramos L (2020) Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias. J Pediatr Urol 16 (5) 689-689. doi.org/10.1016/j.jpurol.2020.07.001



Vilchis F, Mares L, Chávez B, Paredes A, Ramos L (2020) Late-onset vanishing testis-like syndrome in a 38,XX/38,XY agonadic pig (Sus scrofa). Reprod Fertil Dev 32(3) 284-291. doi.org/10.1071/RD18514



Ramos L., Vilchis F., Chávez B., Mares L. (2020) Mutational analysis of SRD5A2: From gene to functional kinetics in individuals with steroid 5α-reductase 2 deficiency. J Steroid Biochem Mol Biol 200: doi.org/10.1016/j.jsbmb.2020.105691



Mares L, Vilchis F, Chávez B, Ramos L (2019) Expression and regulation of ABCG2/BCRP1 by sex steroids in the Harderian gland of the Syrian hamster (Mesocricetus auratus). CR Biol 342: 279-289. doi.org/10.1016/j.crvi.2019.11.003



Mares L, Vilchis F, Chávez B, Ramos L (2019) Isolation and sex steroid effects on the expression of the ATP-binding cassette transporter ABCB6 in Harderian glands of hamster (Mesocricetus auratus). Comp Biochem Physiol A 232: 40-46. doi.org/10.1016/j.cbpa.2019.03.006



Ramos L, Chávez B, Mares L, Valdés E, Vilchis F (2018) Mutational analysis of the androgen receptor (NR3C4) gene in patients with 46,XY DSD. Gene 641: 86-93. doi.org/10.1016/j.gene.2017.10.038