LINEAS DE INVESTIGACIÓN

Nutrigenomica, Nutrigenética y microbiota en diferentes enfermedades relacionadas con la nutrición (obesidad, Síndrome metabólico, diabetes, envejecimiento)


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

Dietary bioactive compounds as modulators of mitochondrial function. Sarai Vasquez, Laura Velazquez. Ariana Vargas, Lilia Noriega, Nimbe Torres, Armando R Tovar. Journal of Nutritional Biochemistry.2021, https://doi.org/10.1016/j.jnutbio.2021.108768

Beneficial effects of seeds and nuts. Diana Itzel Valerio, Mónica Sánchez Tapia, Nimbe Torres y Torres. REDNUTRICION vol 12, num1, ene-abril 2021.

Sex differences in the Physiological network of healthy young subjects. Antonio Barajas, Elizabeth Ibarra, Ruben Fossion, Juan Claudio Toledo, Vania Martinez, Juan Antonio Lopez, Geraldine Tello, Rusland D. Lavin, Jose Luis Gómez, Christopher R Stephens, Carlos Aguilar, Bruno Estañol, Nimbe Torres, Aramando R Tovar, Osbaldo Resendis, Marcia Hiriart, Alejandro Frenk, Ana Leonor Rivera. Frontiers in Physiology, 11 may 2021, doi: 10.3389/phys.2021.678507.

Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. Valeria Lopez, Mónica Sanchez, Sandra Tobon, Daniel Diaz, Gabriela Aleman, Omar Granados, Lilia Noriega, Armando R Tovar, Nimbe Torres. The Journal of Nutritional Biochemistry. 2021. https://doi.org/10.1016/j.jnutbio.2021.108751.

16a-Bromoepiandrosterone as a new candidate for diabetes-tubercolisis comorbidity treatment. Manuel O Lopez Torres, Brenda Marquina, Octavio Ramos, Dulce Mata, Jorge Barrios, Guillermina Baay, Sara Huerta, Cristian Segura, Estela Bini, Ivan Torre, Nimbe Torres, Armando R Tovar, William Chamberlin, Yu Ge, Andrea Carranza, Rogelio Hernandez Pando.Clinical & Experimental Immunology, 2021, DOI: 10.22541/au.160381984.46208315/v1

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation. Lilia Noriega, Zesergio Melo, Renuga D Rajaram, Adriana Mercado, Armando R Tovar, Laura Velazquez, Maria Castañeda, Yazmin Reyes, Dongryeol Ryu, Lorena Rojas, German Magaña, Adriana Lopez, Mariana Sánchez, Anne Debonneville, Alain Doucet, Lydie Cheval, Nimbe Torres, Johan Auwerx, Oliver Staub, Gerardo Gamba. EMBO Reports (2021) e50766.

Serum amino acid concentrations are modified by age, insulin resistance, and BCAT2 rs11548193 and BCKDH rs45500792 polymorphisms in subjects with obesity. Maria R Guizar-Heredia, Armando R Tovar, Omar Granados, Edgar Pichardo-Ontiveros, Adriana Flores-Lopez, Luis E Gonzlez-Salazar, Lilaina Arteaga-Sánchez, Isabel Medina-vera, Ximena Orozco-Ruiz, Nimbe Torers, Lilia Noriega, Martha Guevara-Cruz. Clin Nutr. 2021 Feb 3 ;SO261-5614(21)00064-9, doi: 10.1016/j.clnu.2021.01.037

Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy. Alejandro Schcolnik-Cabrera, Alma Chavez-Blanco, Guadalupe Dominguez-Gomez, Mandy Juarez, Ariana Vargas-Castillo, Rafael Isaac Ponce-Toledo, DonnaLai, Sheng Hua, Armando R Tovar, Nimbe Torres, Delia Perez-Montiel, Jose Diaz-Chavez, Alfonso Dueñas-Gonzalez. Scientific Reports (2021) 11:5222, https://doi.org/10.1038/s41598-021-84538-6.

Effect of a dietary intervention with functional foods on C-LDL concentrations and lipoprotein subclasses in patients with hypercholesterolemia. Results of a controlled trial. Vázquez-Manjarrez Natalia, Guevara Cruz Martha, López Flores Adriana, Tovar Armando, Torres Nimbe, Clinical Nutrition, 2021. https://doi.org/10.1016/j.clnu.2021.02.048

ChREBP downregulates SNAT2 amino acid transporter expression through interactions with SMRT in response to a high-carbohydrate diet. Am J Physiol Endocrinol Metab. 2021 Jan 1;320(1):E102-E112. doi: 10.1152/ajpendo.00326.2020. Epub 2020 Nov 23. PMID: 33225719. Velázquez-Villegas L, Noriega LG, López-Barradas AM, Tobon-Cornejo S, Méndez-García AL, Tovar AR, Torres N, Ortiz-Ortega VM.

Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet. Nutrients. 2021 Dec 24;13(1):38. doi: 10.3390/nu13010038. PMID: 33374283; PMCID: PMC7823885. Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.

PPARα/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation. Metabolism. 2021 Mar;116:154705. doi: 10.1016/j.metabol.2021.154705. Epub 2021 Jan 7. PMID: 33422545. Tobón-Cornejo S, Vargas-Castillo A, Leyva-Martínez A, Ortíz V, Noriega LG, Velázquez-Villegas LA, Aleman G, Furosawa-Carballeda J, Torres N, Tovar AR

Black bean protein concentrate ameliorates hepatic steatosis by decreasing lipogenesis and increasing fatty acid oxidation in rats fed a high fat-sucrose diet. Irma Hernandez-Velazquez, Monica Sanchez-Tapia, Guillermo Ordaz-Nava, Nimbe Torres, Armando R. Tovar and Amanda Galvez . Food Funct, 2020, 11, 10341

Effect of the intake of dietary protein on insulin resistance in subjects

with obesity: a randomized controlled clinical trial. Luis E. Gonzalez‑Salazar, Edgar Pichardo‑Ontiveros, Berenice Palacios‑Gonz.lez, Ana Vigil‑Mart.nez,

Omar Granados‑Portillo, Rocío Guizar‑Heredia, Adriana Flores‑Lopez, Isabel Medina‑Vera, Pamela K. Heredia‑G‑Canton, Karla G. Hernandez‑Gómez, Georgina Castelón‑Licona, Liliana Arteaga‑Sánchez, Aurora E. Serralde‑Zuñiga, Azalia Avila‑Nava,Lilia G. Noriega‑L.pez, Juan G. Reyes‑Garcia, Carlos Zerrweck, Nimbe Torres, Armando R. Tovar, Martha Guevara‑Cruz. European Journal of Nutrition, https://doi.org/10.1007/s00394-020-02428-5

The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet. Mónica Sánchez-Tapia , Aaron W. Miller, Omar Granados-Portillo, Armando R. Tovar & Nimbe Torres. Gut Microbes. 2020, vol 12, No 1, e1801301. doi.org/10.1080/19490976.2020.1801301

Antibiotic treatment reduces the health benefits of soy protein. Monica Sánchez-Tapia, Daniela Moreno-Vicencio, Guillermo Ordáz-Nava, Martha Guevara-Cruz, Omar Granados-Portillo, Ariana Vargas-Castillo, Nimbe Torres, and Armando R. Tovar. Mol Nutr Food Res 2020, doi: 10.1002/mnfr.2000532

Oxalate content and antioxidant activity of different ethnic foods. Azalia Avila-Nava, PhD Isabel Medina-Vera, PhD Pamela Rodrıguez-Hernandez, BS

Martha Guevara-Cruz, PhD, Pamela K. Heredia-G Canton, BS Armando R. Tovar, PhD and Nimbe Torres, PhD. Journal of Renal Nutrition. doi.org/10.1053/jrn.2020.04.006, 2021.

Pros y contras de una dieta cetogénica. Nimbe Torres y Torres, Diana Itzel Valerio-Coronel. REDNUTRICION. Vol 11, num 2, 2020, 734-736.

Consumption of cooked black beans stimulates a cluster of some Clostridia class bacteria decreasing inflammatory response and improving insulin sensitivity. Nutrients 2020, 12, 1182; doi: 10.3390/nu12041182. Mónica Sánchez-Tapia, Irma Hernández-Velázquez, Edgar Pichardo-Ontiveros, Omar Granados, Amanda Gálvez, Armando R. Tovar, Nimbe Torres. Nutrients 2020, 12, 1182; doi:10.3390/nu12041182

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activitation in obese subjects.

Martha Guevara-Cruz, Einar T Godinez-Salas, Monica Sanchez-Tapia, Gonzalo Torres-Villalobos, Edgar Pichardo-Ontiveros, Rocio Guizar-Heredia, Liliana Arteaga-Sanchez, Gerardo Gamba, Raul Mojica-Espinosa, Alejandro Schcolnik-Cabrera, Omar Granados, Adriana L.pez-Barradas, Ariana Vargas-Castillo,Ivan Torre-Villalvazo, Lilia G Noriega, Nimbe Torres, Armando R Tovar. BMJ Open Diab Res Care 2020; 8e000948.doi:10.1136/bmjdrc-2019-000948.

Angiotensin- (1-7) induces beige fat thermogenesis through the Mas receptor. Ariana Vargas-Castillo, Sandra Tobon-Cornejo, Leonardo Del Valle-Mondragon, Ivan

Torre-Villalvazo, Alejandro Schcolnik-Cabrera, Martha Guevara-Cruz, Edgar Pichardo-Ontiveros, Rebeca Fuentes-Romero, Michael Bader, Natalia Alenina, Antonio Vidal-Puig, Enrique Hong, Nimbe Torres, Armando R. Tovar. Metabolism Clinical and Experimental, 2019. https://doi.org/10.1016/j.metabol.2019.154048

Mitos y realidades del aceite de coco. REDNUTRICION. Vol10 numero 1, 2019, 573-574. Nimbe Torres y Torres.

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice.

Palacios-González B, Vargas-Castillo A, Velázquez-Villegas LA, Vasquez-Reyes S, López P, Noriega LG, Aleman G, Tovar-Palacio C, Torre-Villalvazo I, Yang LJ, Zarain-Herzberg A, Torres N, Tovar AR.

J Nutr Biochem. 2019 Jun;68:59-68. doi: 10.1016/j.jnutbio.2019.03.012. Epub 2019 Mar 29.

Development of a Genetic Score to Predict an Increase in HDL Cholesterol Concentration After a Dietary Intervention in Adults with Metabolic Syndrome.

Guevara-Cruz M, Medina-Vera I, Flores-López A, Aguilar-López M, Smith CE, Parnell LD, Lee YC, Lai CQ, Tovar AR, Ordovás JM, Torres N.

J Nutr. 2019 Jul 1;149(7):1116-1121. doi: 10.1093/jn/nxz060.

Nutrigenomics as a tool in the prevention of lipotoxicity: the case of soy protein. Torres N, Torre-Villalvazo I, Tovar AR.

Rev Invest Clin. 2019;71(3):157-167. doi: 10.24875/RIC.18002843.

Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome.

Guevara-Cruz M, Flores-López AG, Aguilar-López M, Sánchez-Tapia M, Medina-Vera I, Díaz D, Tovar AR, Torres N.

J Am Heart Assoc. 2019 Sep 3;8(17):e012401. doi: 10.1161/JAHA.119.012401. Epub 2019 Aug 27.

Diet as Regulator of Gut Microbiota and its Role in Health and Disease. Sánchez-Tapia M, Tovar AR, Torres N. Arch Med Res. 2019 Jul;50(5):259-268. doi: 10.1016/j.arcmed.2019.09.004. Epub 2019 Oct 5. Review.

Natural and artificial sweeteners and high fat diet modify differential taste receptors, insulin, and TLR4-mediated inflammatory pathways in adipose tissues of rats. Sánchez-Tapia, M. Martinez-Medina. J. Tovar, A. R. Torres, N. Nutrients 2019, 11, 880; DOI: 10.3390/nu11040880.

Microbiome-MX 2018: microbiota and microbiome opportunities in Mexico, a megadiverse country. Cornejo-Granados, F. Calderon de la Barca, A.M. Torres, N. Marinez-Romero, E. Torres, J. López-Vidal, Y. Soberon, X. Partida-Martinez, L.P. Pinto-Cardoso, S. Alcaraz, L.D. Pardo-López, L. Canizalez-Quinteros, S. Puente, J. L. Ochoa-Leyva. Research in Microbiology, bolume 170, issue 4-5, june.august 2019, pages 235-241. DOI: 10.1016/j.resmic.2019.03.001.

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice. Palacios-Gonzalez, B., Vargas-Castillo, A., Velazquez-Villegas, L.A., Vasquez-Reyes, S., López, P., Noriega, L.G., Aleman. G., Tovar-Palacio, C., Torre-Villalvazo, I. Yang, L.J. Zarain-Herzberg, A. Torers N, N. Tovar, A.R. Journal of Nutritional Biochemistry. Volume 68, June 2019, pages 59-68.

Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats. Alemán, G, Castro, A. L, Vigil-Martinez, A. Torre-Villalvazo, I., Díaz-Villaseñor, A. Noriega, L. G. Medina-Vera, I., Ordáz, G., Torres, N., Tovar, A.R. Genes and Nutrition vol 14, issue1, 4 junio 2019, DOI: 10.1186/s12263-019-0642-x.

Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome. The Journal of Nutrition. Vol 149, issue 7, 1 julio 2019, pages 1116-1121. DOI: 10.1093/jn/nxz060

A dietary intervention with functional foods reduces metabolic endotoxemia and attenuates biochemical abnormalities by modifying the gut microbiota in subjects with type 2 diabetes. Diabetes & Metabolism. DOI information:10.1016/j.diabet.2018.09.004 Isabel Medina Vera, Mónica Sánchez Tapia, Lilia Noriega-López, Omar Granados-Portillo, Martha Guevara-Cruz, Adriana Flores, Azalia Avila-Nava, Maria Luz Fernández, Armando R Tovar, Nimbe Torres. DOI: 10.1093/jn/nxz060

Genistein modifies gut microbiota, improving glucose metabolism, metabolic endotoxaemia and cognitive function in mice fed a high-fat diet. Mol Nutr Food Rese1800313. doi: 10.1002/mnfr.201800313, 2018. Patricia López, Mónica Sánchez, Claudia Perez-Cruz, Laura A. Velázquez-Villegas, Tauqeerunnisa Syeda, Miriam Aguilar-López, Ana K. Rocha-Viggiano, María del Carmen Silva-Lucero, Ivan Torre, Lilia G. Noriega, Nimbe Torres, Armando R. Tovar

Long term consumption modifies gut microbiota, improving glucose metabolism, metabolic endotoxemia and cognitive function in mice fed a high fat diet. Patricia Lopez; Monica Sanchez; Claudia Perez-Cruz; Laura A.

Velazquez-Villegas; Tauqeerunnisa Syeda; Miriam Aguilar-Lopez,; Ana K. Rocha-Viggiano; Maria del Carmen Silva-Lucero; IvanTorre-Villalvazo; Lilia G. Noriega; Nimbe Torres; Armando R.Tovar.

Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats. Daniela Salinas-Rubio, Armando R.Tovar, Ivan Torre, Omar Granados, Nimbe Torres, Jose Pedraza, Lilia Noriega. Journal of Nutritional Biochemistry, 2018. https://doi.org/0.1016/j.jnutbio.2018.05.011:

Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity. Ivan Torre-Villalvazo, Luz Graciela Cervantes-Pérez, Lilia G. Noriega, Jose V. Jimenez, Norma Uribe, María Chávez-Canales, Claudia Tovar-Palacio, Braulio A. Marfil-Garza, Nimbe Torres, Norma A. Bobadilla, Armando R Tovar and Gerardo Gamba. Am J Physiol Endocrinol Metab 314: E53-E65, 2018; doi: 10.1152/ajpendo.00108.2017.

Adiponectin synthesis and secretion by subcutaneous adipose tissue is impaired during obesity by endoplasmic reticulum stress. Ivan Torre-Villalvazo, Ana E. Bunt, Gabriela Aleman, Claudia C Marquez-Mota, Andrea Díaz-Villaseñor, Lilia G Noriega, Isabela Estrada, Elizabeth Figueroa-Juarez, Claudia Tovar-Palacio, Leonardo Rodriguez-López, Patricia López-Romero, Nimbe Torres, Armando R Tovar. https://doi.org/10.10.1002/jcb.26794. Journal of Cellular Biochemistry. IF 3.085. ISSN: 1097-4644(online).

Amino acid profiles of young adults differ by sex, body mass index and insulin resistance. M Guevara, J Vargas, A. Méndez, A Lopez, O Granados, G Ordaz, A. Rocha, A Gutierrez, E Medina, J Rosado, N Torres, AR Tovar, L Noriega. Nutrition, Metabolism and Cardiovascular Diseases, 2018, Apr; 28(4):393-401

Transporte de aminoácidos: importancia metabólica. Victor Ortiz-Ortega, Lilia Noriega-Lopez, Adriana López, Nimbe Torres, Armando R Tovar. REDNUTRICION. Vol 8 no 23, mayo-ago, 2017, 410-417

Recycling of glucagon receptor to plasma membrane increases in adipocytes of obese rats by soy protein; implications for glucagon resistance. Laura A Velázquez-Villegas, Claudia Tovar, Berencie Palacios, Nimbe Torres, Armando R Tovar, Andrea Díaz. Mol Nutr Food Res. DOI 10.1002/mnfr.201700116.

Understanding the Biology of thermogenci fat: Is browning a new approach to the treatment of obesity? Ariana Vargas-Castillo, Rebeca Fentes-Romero, Leonardo A. Rodriguez-López, Nimbe Torres, Armando R. Tovar. Archives of Medical Research 48(2017), 401-413.

Development and validation of new predictive equation for resting energy expenditure in adults with overweight and obesity. Ximena Orozco-Ruiz, Edgar Pichardo-Ontiveros, Armando R Tovar, Nimbe Torres, Isabel Medina-Vera, Federica Prinelli, Claudio L. Lafortuna, Martha Guevara-Cruz. Clinical Nutrition.. https://doi.org/10.1016/j.clnu.2017.10.022.

Efecto del nopal en la microbiota intestinal en un modelo de obesidad inducida por una dieta alta en grasa saturada y azúcar. Mónica Sánchez Tapia, Nimbe Torres y Torres. REDNUTRICION. Vol 8(23) may-ago 2017, 388-394

Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet. Mónica Sánchez-Tapia, Miriam Aguilar, Sharon Donovan, Armando R Tovar, Nimbe Torres. Sci Reports, julio 2017. Doi: 10.1038/s41598-017-05096-4.

Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress. Adriana Rosas-Villegas ,Mónica Sánchez-Tapia , Azalia Avila-Nava ,Victoria Ramírez ,Armando R. Tovar and Nimbe Torres , Nutrients 2017, 9(4), 393; doi:10.3390/nu9040393

Nopal feeding reduces adiposity, intestinal inflammation and shifts the cecal microbiota and metabolism in high-fat fed rats. Sofia Moran, Xuan He, Elizabeth Chin, Armando R Tovar, Nimbe Torres, Carolyn Slupsky, Helen E Raybould. Plos one 2017. FI=3.23, ISSN 1932-6203.

Clinical, functional, behavioural and epigenomic biomarkers linked to obesity and related metabolic abnormalities. Claudio L Lafortuna, Armando R Tovar, Favio Rastelli, Sarah A Tabozzi, Martina Caramenti, Ximena Orozco Ruiz, Miriam Aguilar López, Martha Guevara Cruz, Azalia Avila Nava, Nimbe Torres, Gloria Bertoli. Frontiers in biosciences, 2017

Food combination based on a prehispanic Mexican diet decreases metabolic and cognitive abnormalities and gut microbiota dysbiosis caused by a sucrose-enriched high fat diet in rats. Avila-Nava Azalia, Noriega LG, Tovar AR, Granados O, Perez-Cruz C, Pedraza-Chaverri José and Torres Nimbe. Molecular Nutrition and Food Research, 2017