Departamento de Fisiología de la Nutrición


Dr. Victor Manuel Ortíz Ortega

54870900 ext 2809
victor.ortizo@incmnsz.mx

GRADO ACADÉMICO: Doctor
CATEGORÍA: Investigador en Ciencias Médicas D
SISTEMA NACIONAL DE INVESTIGADORES Nivel I

 

LINEAS DE INVESTIGACIÓN

Nutrigenómica.

Mecanismos de regulación transcripcional de genes relacionados con el metabolismo de aminoácidos.

Caracterización de la región promotora del gen del transportador de aminoácidos SNAT2.


PUBLICACIONES RELEVANTES DE LOS ULTIMOS 5 AÑOS

Ortiz V, Alemán G, Escamilla-Del-Arenal M, Recillas-Targa F, Torres N, Tovar AR. Promoter characterization and role of CRE in the basal transcription of the rat SNAT2 gene. Am J Physiol Endocrinol Metab. 2011; 300: E1092-E1102.

Gonzalez-Granillo M, Steffensen KR, Granados O, Torres N, Korach-Andre M, Ortiz V, Aguilar-Salinas C, Jakobsson T, Diaz-Villaseñor A, Loza-Valdes A, Hernandez-Pando R, Gustafsson JA, Tovar AR. Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice. Diabetologia 2012; 55(9): 2469-2478.

Aleman G, Ortiz V, Contreras AV, Quiroz G, Ordaz-Nava G, Langley E, Torres N, Tovar AR. Hepatic amino acid-degrading enzymes expression is downregulated by natural and synthetic ligands of PPAR in rats. J Nutr 2013; 143: 1211-1218.

Velázquez-Villegas LA, Ortiz V, Ström A, Torres N, Engler DA, Matsunami R, Ordaz-Rosado D, García-Becerra R, López-Barradas AM, Larrea F, Gustafsson JA, Tovar AR. Transcriptional regulation of the sodium-coupled neutral amino acid transporter (SNAT2) by 17β-estradiol. Proc Natl Acad Sci 2014; 111(31): 11443-11448.

Cázares-Ordoñez V, González-Duarte RJ, Díaz L, Ishizawa M, Uno S, Ortíz V, Ordoñez-Sánchez ML, Makishima M, Larrea F, Avila E. A cis-acting element in the promoter of human ether à go-go 1 potassium cannel gene mediates repression by calcitriol in human cervical cancer cells. Biochem Cell Biol. 2015; 93(1): 94-101.

Contreras AV, Rangel-Escareño C, Torres N, Alemán-Escondrillas G, Ortiz V, Noriega LG, Torre-Villalvazo I, Granados O, Velázquez-Villegas LA, Tobon-Cornejo S, González-Hirschfeld D, Recillas-Targa F, Tejero-Barrera E, Gonzalez FJ, Tovar AR. PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis. Genes Nutr 2015; 10(2): 452.

Velázquez-Villegas LA, López-Barradas AM, Torres N, Hernández-Pando R, León-Contreras JC, Granados O, Ortíz V, Tovar AR. Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino acid transporter in the mammary gland during lactation. Biochim Biophys Acta. 2015; 1848(5): 1157-1164.

Escalona-Nández I, Guerrero-Escalera D, Estánes-Hernández A, Ortíz-Ortega V, Tovar AR, Pérez-Monter C. The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions. Biochem Biophys Res Commun. 2015; 458(4): 751-756.

González-Duarte RJ, Cázares-Ordoñez V, Romero-CórdobaS, Díaz L, Ortiz V, Freyre-González JA, Hidalgo-Miranda A, Larrea F, Avila E. Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa cervical cáncer cells. Biochem Cell Biol 2015; 93(4): 376-384.

González-Duarte RJ, Cázares-Ordoñez V, Díaz L, Ortiz V, Larrea F, Avila E. The expression of RNA helicase DDX5 is transcriptionally upregulated by calcitriol through a vitamin D response element in the proximal promoter in SiHa cervical cells. Mol Cell Biochem 2015; 410(1-2): 65-73